User contributions for Oro Temp
A user with 310 edits. Account created on 13 August 2022.
11 June 2024
- 02:3702:37, 11 June 2024 diff hist +867 Baclofen →Pharmacodynamics: Improved this section to remove the unnecessary and somewhat misleading refrence to phenibut as a GABA-B agonist in the same vein as baclofen. Rewrote this section to emphasize baclofen's selectivity for GABA-B to be consistent with research cited in a later paragraph. Tag: Visual edit
9 June 2024
- 00:5800:58, 9 June 2024 diff hist −28 m Tropomyosin receptor kinase B →Agonists: Removed selegiline from this list. While there is evidence that selegiline indirectly increases BDNF levels and TRKB signaling, there is no evidence of direct agonistic activity. current Tag: Visual edit
- 00:5400:54, 9 June 2024 diff hist −20 Tropomyosin receptor kinase B →Others: Renamed this section to Positive Allosteric Modulators. All compounds listed here previously (with the exception of DHEA) are described as binding to an allosteric site on TRKB and enhancing endogenous signaling. I've moved DHEA to another "other" section, although from what I've read it appears to bind with no intrinsic activity (though it was not explicitly called an antagonist). Tag: Visual edit
24 May 2024
- 17:4317:43, 24 May 2024 diff hist +1,148 Draft:RG3487 No edit summary current Tag: Visual edit
20 May 2024
- 03:2503:25, 20 May 2024 diff hist −134 Benzofuranylpropylaminopentane Removed "it can be loosely grouped in with the stimulant and antidepressant classes". The previous author seems to think that the antidepressant class is defined by certain pharmacological properties, when this is not the case. BPAP is not nearly characterized enough to classify or disqualify it as an antidepressant. Tag: Visual edit
- 03:1903:19, 20 May 2024 diff hist +27 Benzofuranylpropylaminopentane Improved first sentence to include that BPAP is both a monoamine activity enhancer AND a monoamine reuptake inhibitor (this previously implied that it was only a MAE). Tag: Visual edit
- 02:5702:57, 20 May 2024 diff hist −4 Fluorenol →Sale as research chemical: Fluorenol bears modafinil's pharmacophore, but is not a substituted derivative of it. Tag: Visual edit
29 April 2024
- 01:0001:00, 29 April 2024 diff hist +882 Tachyphylaxis →Examples: Added info about methylphenidate acute tachyphylaxis which remits within a 24 hour period. Tag: Visual edit
- 00:5500:55, 29 April 2024 diff hist +447 Drug tolerance →Pharmacodynamic tolerance: Added the contribution of mechanisms beyond receptor desensitisation in formation of tolerance Tag: Visual edit
19 April 2024
- 00:0100:01, 19 April 2024 diff hist +276 Anorectic →List of anorectics: Added a better source than "Mens health magazine" for caffeine. Many other entries on this list require citations. Tag: Visual edit
18 April 2024
- 23:5723:57, 18 April 2024 diff hist +453 Anorectic →List of anorectics: Added info about lisdexamphetamine being approved for the treatment of binge eating disorder in adults. Tag: Visual edit
- 19:2019:20, 18 April 2024 diff hist −18 m Bromantane Actoprotectors are synthetic adaptogens. Classifying bromantane as both is redundant. Bromantane has been preferentially referred to as an actoprotector in the literature. current Tag: Visual edit
14 April 2024
- 20:1120:11, 14 April 2024 diff hist +225 Draft:Desmethylzopiclone Submitting using AfC-submit-wizard
- 20:1120:11, 14 April 2024 diff hist +28 N Draft talk:Desmethylzopiclone Adding WikiProject tags using AfC-submit-wizard current
- 20:1020:10, 14 April 2024 diff hist +1,432 Draft:Desmethylzopiclone Added more information (forensics, anxioselectivity, GABA subtypes) for submission Tag: Visual edit
- 19:4819:48, 14 April 2024 diff hist +87 Draft:Desmethylzopiclone No edit summary Tag: Visual edit
31 March 2024
- 00:5600:56, 31 March 2024 diff hist +369 Slow-wave sleep →Drugs: Attempted to clean up this section to be more readable and factual. It still needs some work, though. We might be better off replacing these repetitive descriptions with a list of drugs that enhance SWS instead. Tag: Visual edit
18 March 2024
- 17:3917:39, 18 March 2024 diff hist +635 Modafinil →Abstinence in cocaine addiction: Added information about modafinil's sleep-normalising effects in cocaine-dependent individuals undergoing withdrawal. Tag: Visual edit
17 March 2024
- 23:1723:17, 17 March 2024 diff hist +26 m Delta-sleep-inducing peptide →Roles in physiological processes: Changed "Paradoxical Sleep" to "rapid eye movement sleep". Both are correct, but PS is less recognisable. current Tag: Visual edit
- 19:1319:13, 17 March 2024 diff hist −102 User:Oro Temp No edit summary current Tag: Visual edit
16 March 2024
- 04:0204:02, 16 March 2024 diff hist +2 m Modafinil →Bipolar disorder: Fixed sentence to incorporate prev edit. Tag: Visual edit
- 04:0104:01, 16 March 2024 diff hist −4 Modafinil Bipolar disorder: 'Mood switch' in this paper refers to a switch from depression to mania or vice versa. It cannot be likened to 'mood swing' as was linked. I Tag: Visual edit
- 03:5403:54, 16 March 2024 diff hist −10 m Modafinil Removed redundant (research) heading for a subsection of the research section Tags: Reverted Visual edit
- 03:5103:51, 16 March 2024 diff hist +618 Modafinil →Occupational: Added information about modafinil's sanctioned use on the International Space Station for the management of fatigue Tag: Visual edit
9 March 2024
- 21:0421:04, 9 March 2024 diff hist +1,433 Beta blocker →Blood–brain barrier permeability: Added information about lipophilic Beta-1 antagonists reducing melatonin release. Tag: Visual edit
4 March 2024
- 20:3520:35, 4 March 2024 diff hist −230 Ibutamoren →Non-research use: Removed unrelated statement which contained factual errors such as "MK-677 acts as a neuropeptide", contradicted by the fact that MK-677 is a non-peptide agonist of the ghrelin receptor. Tag: Visual edit
- 20:3320:33, 4 March 2024 diff hist +39 Theacrine →Pharmacodynamics Tag: Visual edit
- 20:3220:32, 4 March 2024 diff hist −25 Theacrine →Pharmacodynamics: Removed "citation needed", providing a citation here would be considered promoting a commercial source and misinformation due to the nature of the claim. The claim is supported by a previous citation in the sentence before that would be redundant to repeat. Tag: Visual edit
- 20:3120:31, 4 March 2024 diff hist +610 Talk:Theacrine →"Citation needed", but providing the citation would be considered promoting a commercial source.: new section current Tag: New topic
- 20:2720:27, 4 March 2024 diff hist +1,417 Methylliberine Organised this page better and added information about methylliberine's pharmacological actions Tag: Visual edit
30 January 2024
- 21:5421:54, 30 January 2024 diff hist +792 Phenylpropylaminopentane No edit summary Tag: Visual edit
- 21:2121:21, 30 January 2024 diff hist +36 Benzofuranylpropylaminopentane Emphasized the preclinical nature of BPAP's research. Tag: Visual edit
- 21:1621:16, 30 January 2024 diff hist +32 m Selegiline Added crosslink to wikipedia page for Monoamine activity enhancer Tag: Visual edit
17 January 2024
- 02:0602:06, 17 January 2024 diff hist +590 Adenosine receptor agonist Added Rosmarinic acid to the list of adenosine receptor agonists Tag: Visual edit
23 December 2023
- 18:1518:15, 23 December 2023 diff hist +204 AOD9604 Submitting using AfC-submit-wizard
- 18:1518:15, 23 December 2023 diff hist +103 N Talk:AOD9604 Adding WikiProject tags using AfC-submit-wizard
- 18:1118:11, 23 December 2023 diff hist +1,958 AOD9604 Creation of AOD9604, a lipolytic peptide fragment of human growth hormone trialed as a treatment for obesity. Tag: Visual edit
- 18:0018:00, 23 December 2023 diff hist −520 HGH Fragment 176–191 No edit summary Tag: Visual edit
- 17:5317:53, 23 December 2023 diff hist −1,324 HGH Fragment 176–191 I have thoroughly corrected this article. HGH-frag 176-191 has erroneously been referred to as a synonym for AOD9604. This misunderstanding is propagated by grey area peptide vendors wishing to misrepresent human AOD9604 research as evidence of HGH-frag 176-191's efficacy. I mistakenly assumed AOD9604 was a developmental name for HGH-frag 176-191. Their differences are non-negligible, but easily missed. I've since separated and distinguished these articles. Tag: Visual edit
- 17:2517:25, 23 December 2023 diff hist +975 N AOD9604 -- Draft creation using the WP:Article wizard -- Tag: Visual edit
- 16:4516:45, 23 December 2023 diff hist +819 Tropisetron Tropisetron is a partial agonist of a7 nicotinic receptors, I've added this detail. There is also some preliminary evidence supporting the notion that tropisetron may have a modulating or co-agonist action at a7 receptors. Tag: Visual edit
- 15:5815:58, 23 December 2023 diff hist −11 m Temgicoluril Made a minor edit to remove "has not been evaluated by the American medical system" (?) which has no meaning given that "the American medical system" is not a regulatory body in the United States. This article is almost completely based on outdated pharmacological understandings and needs review. Tag: Visual edit
- 10:3510:35, 23 December 2023 diff hist +829 N Draft:RG3487 -- Draft creation using the WP:Article wizard -- Will revisit at a later time to finish this entry Tag: Visual edit
22 December 2023
- 21:3021:30, 22 December 2023 diff hist −57 m Pozanicline Removed "Making it an exciting compound". Wikipedia articles should not be suggestive. current Tag: Visual edit
- 19:0719:07, 22 December 2023 diff hist −21 GTS-21 →Clinical trials: Reworded research section with misplaced transition "GTS-21 has also been studied in humans" following a section summarising a clinical trial. Tag: Visual edit
19 December 2023
- 13:0213:02, 19 December 2023 diff hist −33 Thozalinone Reworded “unlike other stimulants” to emphasise that this anolog is itself a dopaminergic stimulant. Tags: Mobile edit Mobile app edit iOS app edit
18 December 2023
- 18:0318:03, 18 December 2023 diff hist +588 Light effects on circadian rhythm →Mechanism: Added information about age-related crystalline lense yellowing and its implications in age-related changes in circadian phenotype. Tag: Visual edit
16 December 2023
- 19:4119:41, 16 December 2023 diff hist +637 Talk:5-HT2C receptor →This page is ripe with armchair pharmacology: new section Tag: New topic
9 December 2023
- 17:2617:26, 9 December 2023 diff hist +2,024 Gaboxadol Added pharmacology section. The intro section is written too suggestively, 'harnessing the power of gaboxadol' should be reserved for a psychopharmacologist's comic book, not Wikipedia (though I can relate to excitement). Tag: Visual edit
- 16:5316:53, 9 December 2023 diff hist +64 m TPA-023 Reworded sentences explaining the pharmacology of TPA-023, which implied that TPA-023 acted as a positive allosteric modulator to benzodiazepine receptors as well as using the phrasing "a2 and a3 GABA-A receptors". a2 and a3 are subunits, the correct terminology is "a2 and a3-containing GABA-A receptors". Tag: Visual edit
