| Year
|
Title
|
Contributors
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Journal
|
Highlights and notes
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DOI
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| 2018
|
Divergent prefrontal dopaminergic mechanisms mediate drug- and fear-associated cue extinction during adolescence versus adulthood
|
Zbukvic IC, & Kim JH
|
European Neuropsychopharmacology. In press
|
Anxiety & Addiction.
|
[1]
|
| 2018
|
Developmental perspectives on methamphetamine abuse: Exploring adolescent vulnerabilities on brain and behavior
|
Luikinga SJ, Kim JH, & Perry CJ
|
Progress in Neuropsychopharmacology & Biological Psychiatry. In press.
|
Addiction. Methamphetamine use usually begins in adolescence, and earlier onset is associated with increased risk of developing a substance use disorder. Methamphetamine exposure causes volumetric and neurotransmitter changes in regions that are developing during adolescence. Dopamine cell loss following acute meth exposure is lower in adolescents than adults.
|
[2]
|
| 2017
|
Juvenile female rats, but not male rats, show renewal, reinstatement, and spontaneous recovery following extinction of conditioned fear
|
Park JCH, Ganella DE, & Kim JH
|
Learning & Memory. In press.
|
Anxiety.
|
[3]
|
| 2017
|
Investigating the role of dopamine receptor- and parvalbumin-expressing cells in extinction of conditioned fear
|
Madsen HB, Guerin A, Kim JH
|
Neurobiology of Learning and Memory. 145: 7-17
|
Anxiety. Extinction increased Fos+ and decreased D2R+ cells in the infralimbic cortex. Fear retrieval increased Fos labeling of D2R+ cells in the prelimbic cortex. Context exposure, retrieval, and extinction display overlapping neural activation.
|
[4]
|
| 2017
|
Aripiprazole facilitates extinction of conditioned fear in adolescent rats
|
Ganella DE, Lee-Kardashyan L, Luikinga SJ, Nguyen DLD, Madsen HB, Zbukvic IC, Coulthard R, Lawrence AJ, & Kim JH
|
Frontiers in Behavioral Neuroscience. 11: 76.
|
Anxiety.
|
[5]
|
| 2017
|
A dissociation between renewal and contextual fear conditioning in juvenile rats
|
Park JCH, Ganella DE, & Kim JH
|
Developmental Psychobiology. 59: 515-522
|
Anxiety.
|
[6]
|
| 2017
|
Prefrontal dopaminergic mechanisms of fear extinction in adolescence compared to adulthood in rats
|
Zbukvic IC, Park JCH, Ganella DE, Lawrence AJ, & Kim JH
|
Frontiers in Behavioral Neuroscience. 11: 32
|
Anxiety.
|
[7]
|
| 2017
|
Extinction of conditioned cues attenuates incubation of craving in adolescent and adult rats
|
Madsen HB, Zbukvic IC, Luikinga SJ, Lawrence AJ, & Kim JH
|
Neurobiology of Learning and Memory. 143: 88-93
|
Addiction. Adolescent and adult rats self-administer similar amounts of cocaine. Adolescent rats are impaired in lever discrimination for cocaine Incubation of cocaine-seeking was similar in adolescent and adult rats. Aripiprazole injection did not facilitate cue extinction.
|
[8]
|
| 2017
|
In vivo prion models and the disconnection between transmissibility versus neurotoxicity
|
Senesi M, Lewis V, Kim JH, Adlard P, Finkelstein DI, & Collins SJ
|
Ageing Research Reviews. 36: 156-164
|
Separate species of PrPSc underpinning prion transmission and neurotoxicity is under debate. Potential new target for treatment can be defined for each of the species. Novel animal modelling may uncover other factors influencing prion disease pathogenesis
|
[9]
|
| 2017
|
Exercise alters mouse sperm microRNAs and induces a transgenerational modification of male offspring conditioned fear and anxiety
|
Short AK, Yeshurun S, Powell R, Perreau VM, Fox A, Kim JH, Pang TY, & Hannan AJ
|
Translational Psychiatry. 7: e1114
|
Anxiety.
|
[10]
|
| 2017
|
Reducing fear during childhood to prevent anxiety disorders later: Insights from developmental psychobiology
|
Kim JH
|
Policy Insights from the Behavioral and Brain Sciences. 4, 131-138
|
Anxiety. Anxiety disorders are neurodevelopmental with the median age of onset 10 to 11 years. Extinction processes that are involved in cognitive-behavioral therapy appear particularly effective in children compared with older populations. Policy should mandate school psychologists and government subsidies for therapy sessions to increase children’s mental-health-service utilization.
|
[11]
|
| 2017
|
Postnatal development of neurotransmitter systems and their relevance to extinction of conditioned fear
|
Kim JH, Perry CJ, 2zGanella DE, Madsen HB
|
Neurobiology of Learning and Memory. 138: 252-270
|
Anxiety. elapse-resistant extinction in juvenile rodents may be due to high NMDA-NR2B, mGlu5, and/or nicotinic receptor signaling in the amygdala. Extinction deficit in adolescence may be due to low NMDA-NR2B, and/or low D2R relative to D1R signaling in the PFC.Changes in the localization of oxytocin receptors in the amygdala may explain transition from effective to ineffective extinction across development.
|
[12]
|
