User:Mr. Ibrahem/Galantamine
Clinical data | |
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Trade names | Razadyne, Reminyl, GalantaMind, others |
Other names | Galantamine hydrobromide |
AHFS/Drugs.com | Monograph |
MedlinePlus | a699058 |
License data | |
Pregnancy category |
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Routes of administration | By mouth |
Drug class | Anticholinesterase inhibitor[2] |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | 80–100% |
Protein binding | 18% |
Metabolism | Liver partially CYP450:CYP2D6/3A4 substrate |
Elimination half-life | 7 hours |
Excretion | Kidney (95%, of which 32% unchanged), fecal (5%) |
Identifiers | |
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Chemical and physical data | |
Formula | C17H21NO3 |
Molar mass | 287.359 g·mol−1 |
3D model (JSmol) | |
Melting point | 126.5 °C (259.7 °F) |
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Galantamine, sold under the brand name Razadyne among others, is a medication used to treat mild to moderate Alzheimer's disease.[4][5] It may be used in dementia with Lewy bodies if other treatments are not tolerated.[2] In mild cognitive impairment it may worsen outcomes.[4] It is taken by mouth.[4]
Common side effect include arrhythmias, depression, diarrhea, sleepiness, hallucinationss, high blood pressure, and tremor.[2] Other side effects may include gastrointestinal bleeding, urinary retention, seizures, and Stevens-Johnson syndrome.[4] It is an anticholinesterase inhibitor which increases acetylcholine at cholinergic synapses in the brain.[2][4]
Galantamine was approved for medical use in the United States in 2001.[4] It is available as a generic medication.[2] In the United Kingdom it costs the NHS up to £80 for 4 weeks as of 2021.[2] This amount in the United States costs about 66 USD.[6]
References[edit]
- ^ a b "Galantamine Use During Pregnancy". Drugs.com. 18 February 2019. Archived from the original on 25 February 2020. Retrieved 24 February 2020.
- ^ a b c d e f g h i BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 318. ISBN 978-0857114105.
- ^ "Archive copy" (PDF). Archived (PDF) from the original on 2021-10-31. Retrieved 2021-09-26.
{{cite web}}
: CS1 maint: archived copy as title (link) - ^ a b c d e f g "Galantamine Monograph for Professionals". Drugs.com. Archived from the original on 19 October 2021. Retrieved 2 December 2021.
- ^ Birks J (January 2006). Birks JS (ed.). "Cholinesterase inhibitors for Alzheimer's disease". The Cochrane Database of Systematic Reviews (1): CD005593. doi:10.1002/14651858.CD005593. PMID 16437532.
- ^ "Galantamine Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 19 October 2021. Retrieved 2 December 2021.