User:Zasan001/sandbox

Edits

For Developmental Psychology:

Added: Like wise, the long-standing notion "cells that fire together, wire together" derives from Hebbian theory which asserts that synaptogenesis, a process with great epigenetic precedence, depends on the activity of the respective synapses within a neural network. Where experience alters the excitability of neurons, increased neural activity has been linked to demethylation.

Added: Although empirical studies have yielded discrepant results, epigenetic modifications are thought to be a biological mechanism for transgenerational trauma.

Added: Decreased DNMT activity decreases methylation in the hippocampus and diminished the level of long-term potentiation that occurs.

Genomic Imprinting:

Original: Rett syndrome is underlain by mutations in the MECP2 gene despite no large-scale changes in expression of MeCP2 being found in microarray analyses. BDNF is downregulated in the MECP2 mutant resulting in Rett syndrome, MeCP2 deletion has been shown to increase seen in Rett syndrome.

Edit: Methyl CpG-binding protein 2 (MeCP2) is a transcriptional regulator that must be phosphorylated before releasing from the BDNF promoter, allowing transcription during important developmental events like synaptogenesis. Rett syndrome is underlain by mutations in the MeCP2 gene despite no large-scale changes in expression of MeCP2 being found in microarray analyses. BDNF is downregulated in the MECP2 mutant resulting in Rett syndrome, as well as the increase of early neural senescence and accumulation of damaged DNA.